Micky van de Ven Brace Halts Everton's Run at New Home Ground
The Dutch defender became the initial backline player to score two goals in a Premier League match for Tottenham since the Belgian defender in March 2013.
At a glance
Micky Van de Ven nods home two times in first half
Everton's Jake O'Brien has goal disallowed after video check
Senegalese midfielder scores final goal in dying moments
This loss is Everton's first at Hill Dickinson Stadium
The Tottenham defender scored on two occasions as Tottenham extended their winning streak on the road in the Premier League and delivered Everton their initial loss at their new home.
The Toffees were undefeated in their five previous fixtures at their recently opened stadium at the dockside location, having left their historic home behind after 133 years at the conclusion of last season.
But Spurs captain Van de Ven struck on two occasions from set-pieces in the first half to put their strong form at jeopardy, and they were failed to turn it around before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - nodded in a final goal to seal the victory.
The Everton defender thought he had equalized the tally five minutes after the defender's opener, directing a bullet header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, in the meantime, missed a handful of opportunities, while the Italian goalkeeper made a series of excellent stops to ensure the London club went five matches on the road without defeat in the English top flight.
But the video assistant referee stepped in, instructing Craig Pawson to check the goal on the screen and the official ruled that the winger and Iliman Ndiaye were in offside positions and had interfered with the Spurs keeper.
The win elevates Thomas Frank's side into third place in the Premier League, five points off local foes and leaders the Gunners.
Everton remain 14th and are six points ahead of the drop zone.
Spurs breakdown: The defender excels in role at both ends of the field
Following a drab midweek performance in the European competition against the French side, where they mustered a only attempts on goal, the manager chose the French striker in attack instead of ex-Everton forward the Brazilian.
The summer signing was unable to influence the game before being replaced for the substitute after 60 minutes on the pitch, but it emerged he wasn't needed in the final outcome.
Defender the Dutchman converted into an offensive threat to be feared.
Spurs' opening strike came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball toward the face of goal for an free Van de Ven to score.
And Ven de Ven - filling in as skipper in the Argentine's absence - notched his next goal in added time as he outjumped the England keeper to nod in.
Van de Ven was equally impressive in defensive duties, combining well with Kevin Danso as the duo dealt superbly with the 34 crosses thrown their way by the opposition.
Everton analysis: Toffees missing striker's instinct
The club's recent stadium had been a happy hunting ground, but it seems the freshness may have faded somewhat and fans headed to the exits after Sarr's final goal for Tottenham.
The end in Everton's unbeaten home run will not be a major concern for David Moyes, but their attacking woes will be.
The forward and Thierno Barry - the Everton's two established centre-forwards - had netted just one league goal between them before the weekend's match.
And they were unable to add to that miserable record on a damp and dreary evening on Merseyside.
Beto's form was epitomized when he opted to bicycle-kick a clear chance from close range, despite having space and time to readjust for a more conventional attempt that would have challenged Vicario.
Barry, too, failed to make an impact after coming on for the starter in the second half.
It was not for a lack of opportunity. The majority of Everton's offensive moves came through the winger and Ndiaye, who tirelessly delivered threatening crosses into the Tottenham penalty area.
Upcoming fixtures for these two sides?
The Toffees: The team head to Sunderland in the Premier League on early November at 20:00 GMT.
Spurs: Spurs travel to St James' Park on Wednesday, 29 October for their fourth-round Carabao Cup match against the Magpies.